Name | Fenticonazole nitrate |
Synonyms | Falvin Lomexin Fentigyn Fentiderm Rec-15—1476 Fenticonazol Nitrate Fenticonazole nitrate FENTICONAZOLE NITRATE 1-(2-(2,4-DICHLOROPHENYL)-2-((4-(PHENYLTHIO)BENZYL)OXY)ETHYL)-1H-IMIDAZOLE 1-[2-(2,4-dichlorophenyl)-2-{[4-(phenylsulfanyl)benzyl]oxy}ethyl]-1H-imidazole 1-[2-(2,4-Dichlorophenyl)-2-[(4-phenylsulfanylphenyl)methoxy]ethyl]imidazole nitrate 1-[2-(2,4-dichlorophenyl)-2-[[4-(phenylthio)phenyl]methoxy]ethyl]-1H-imidazolium nitrate 1-[2-(2,4-Dichlorophenyl)-2-[[4-(phenylthio)phenyl]methoxy]ethyl]-1H-imidazole mononitrate |
CAS | 73151-29-8 724729-26-6 |
EINECS | 277-302-6 |
InChI | InChI=1/C24H20Cl2N2OS/c25-19-8-11-22(23(26)14-19)24(15-28-13-12-27-17-28)29-16-18-6-9-21(10-7-18)30-20-4-2-1-3-5-20/h1-14,17,24H,15-16H2 |
InChIKey | FJNRUWDGCVDXLU-UHFFFAOYSA-N |
Molecular Formula | C24H21Cl2N3O4S |
Molar Mass | 518.41 |
Density | 1.26g/cm3 |
Melting Point | 135-137°C |
Boling Point | 637.2°C at 760 mmHg |
Flash Point | 339.2°C |
Solubility | Practically insoluble in water, freely soluble in dimethylformamide and in methanol, sparingly soluble in anhydrous ethanol |
Vapor Presure | 1.93E-15mmHg at 25°C |
Appearance | neat |
Color | White to Pale Yellow |
Merck | 14,4005 |
pKa | 6.54(at 25℃) |
Storage Condition | Inert atmosphere,Room Temperature |
Refractive Index | 1.632 |
Physical and Chemical Properties | White crystalline powder, odorless. Melting point 136 °c. Solubility at 20 °c (mg/ml): Water <0.1. Ether <0.1, ethanol 30, chloroform 300, dimethylformamide 600. UV absorption maximum (methanol):252nm (n13894). PKA 6.54. Acute toxicity LD50 mice, male rats, female rats (mg/kg):1191,440,309 intraperitoneal injection; All> 3000 oral. broad spectrum. It is effective against dermatophytes, yeasts, and other fungi that cause dermatomycosis. It is used for dermatomycosis, Tinea corporis and infections caused by dermatophytes, yeasts and other fungi. after reduction of 2, 4-dichlorophenyl-α-chloroethanone with sodium borohydride, it is condensed with imidazole first, and then with 4-chloromethyldiphenyl sulfide to give fenconazole. |
RTECS | NI4780000 |
Toxicity | LD50 in mice, male rats, female rats (mg/kg): 1191, 440, 309 i.p.; all >3000 orally (Graziani) |